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Coronary artery disease associated transcription factor TCF21 regulates smooth muscle precursor cells that contribute to the fibrous cap

2015; Elsevier BV; Volume: 5; Linguagem: Inglês

10.1016/j.gdata.2015.05.007

2213-5960

Sylvia Nürnberg, Kailin Cheng, Azad Raiesdana, Ramendra Kundu, Clint L. Miller, Juyong Brian Kim, Kanika Arora, Iván Cárcamo-Orive, Yuning Xiong, Nikhil Tellakula, Vivek Nanda, Nikitha Murthy, William A. Boisvert, Ulf Hedin, Ljubica Perisic, Silvia Aldi, Lars Mäegdefessel, Milos Pjanic, Gary K. Owens, Michelle D. Tallquist, Thomas Quertermous,

Cancer-related molecular mechanisms research

TCF21 is a basic helix–loop–helix transcription factor that has recently been implicated as contributing to susceptibility to coronary heart disease based on genome wide association studies. In order to identify transcriptionally regulated target genes in a major disease relevant cell type, we performed siRNA knockdown of TCF21 in in vitro cultured human coronary artery smooth muscle cells and compared the transcriptome of siTCF21 versus siCONTROL treated cells. The raw (FASTQ) as well as processed (BED) data from 3 technical replicates per treatment has been deposited with Gene Expression Omnibus (GSE44461).