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Personalized Nanoparticles for Cancer Therapy: A Call for Greater Precision

2017; Bentham Science Publishers; Volume: 17; Issue: 8 Linguagem: Inglês

10.2174/1871520617666170102150730

1875-5992

Nare Sahakyan, Amir Haddad, Shye Richardson, Valery Forcha-Etieundem, Lee Christopher, Hanan M. Alharbi, R. B. Campbell,

Chemical Reactions and Isotopes

Nanotechnology has brought about the advent of personalized medicine in the era of targeted therapeutic strategies for cancer therapy. The ability to exploit tumor features for therapeutic gain has made it possible to manufacture more effective nanomedicines for cancer treatment. However, known obstacles, including the inability to overcome pathophysiological barriers of tumors, have impeded disease management. In spite of this, recent efforts have been made to develop more functionalized nanosystems that utilize the active-targeting approach. This article reviews the FDA-approved cancer drug delivery systems in the general framework of personalized nanomedicine. We discuss the latest efforts in the development of functionalized nano-systems, and summarize relevant ongoing preclinical and clinical trials. Keywords: Personalized medicine, cancer therapy, drug delivery, nanoparticles, tumor-targeted nanomedicines, nanotechnology.