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Artigo Produção Nacional Revisado por pares
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Antinociceptive effect of Aristolochia trilobata stem essential oil and 6-methyl-5-hepten-2yl acetate, its main compound, in rodents

2017; De Gruyter; Volume: 72; Issue: 3-4 Linguagem: Inglês

10.1515/znc-2016-0053

ISSN

1865-7125

Autores

Jullyana de Souza Siqueira Quintans, Rafael dos Santos Alves, Darlisson de Alexandria Santos, Mairim Russo Serafini, Péricles Barreto Alves, Emmanoel Vilaça Costa, Gökhan Zengin, Lucindo José Quintans‐Júnior, Adriana Gibara Guimarães,

Tópico(s)

Medicinal Plant Extracts Effects

Resumo

Abstract Aristolochia trilobata L. is an aromatic plant, popularly known as “mil-homens”, and its essential oil (EO) is generally used to treat colic, diarrhea and dysentery disorders. We evaluated the antinociceptive effect of A. trilobata stem EO and of its major compound, the (R)-(-)-6-methyl-5-hepten-2-yl acetate (sulcatyl acetate: SA), using acetic acid (0.85%)-induced writhing response and formalin-induced (20 μL of 1%) nociceptive behavior in mice. We also evaluated the EO and SA effect on motor coordination, using the rota-rod apparatus. EO (25, 50 and 100 mg/kg) or SA (25 and 50 mg/kg) reduced nociceptive behavior in the writhing test ( p <0.001). EO (100 mg/kg) and SA (25 and 50 mg/kg) decreased the nociception on the first phase of the formalin test ( p <0.05). On the second phase, EO (25: p <0.01; 50: p <0.05 and 100 mg/kg: p <0.001) and SA (25 and 50 mg/kg; p <0.001) reduced the nociceptive response induced by formalin. EO and SA were not able to cause changes in the motor coordination of animals. Together, our results suggest that EO has an analgesic profile and SA seems to be one of the active compounds in this effect.

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