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OP - CD44 EXPRESSION AND ITS ASSOCIATION TO CLINICOPATHOLOGICAL FEATURES AND SURVIVAL IN ORAL SQUAMOUS CELL CARCINOMA

2017; Elsevier BV; Volume: 123; Issue: 2 Linguagem: Inglês

10.1016/j.oooo.2016.09.034

2212-4411

Sandra Ventorin von Zeidler, José Roberto Vasconcelos de Podestá, Daniely Souza De Nardi, Priscila Marinho de Abreu, MARCELLA SOL, Sônia Alves Gouvêa, Danielle Resende Camisasca,

Oral Health Pathology and Treatment

Numerous attempts have been made to establish and develop tumor markers with prognostic significance. This study aimed to investigate CD44 expression in primary oral squamous cell carcinoma and evaluate its association with clinicopathological factors, as well as its prognostic value during long-term follow-up. Surgical specimens from patients with oral squamous cell carcinoma (n=68) were immunostained for CD44. Comparative analyses of CD44 expression, microscopic features and tumor stage were performed using Spearman´s correlation and Chi-square tests (P<0.05). Disease-specific survival (DSS) and disease-free survival (DFS) were estimated using the Kaplan-Meier method. Comparison of DSS and DFS with the features analyzed was achieved via the Log-Rank test. The results revealed decreased CD44 expression in well-differentiated tumors (P=0.005). Spearman´s correlation demonstrated a negative association between CD44 expression and N-stage, showing reduced and diffuse CD44 staining in tumor islands (r = -0.414; P = 0.003). There was no correlation between CD44 expression, T-stage or histological grade. In addition, there was no association between CD44 expression and survival. In conclusion, CD44 expression was not considered a strong prognostic marker in multivariate analysis, which should be further evaluated for use in clinical practice. Financial Support: CAPES and FAPES.