CRISPR-Cas9 gene repair of hematopoietic stem cells from patients with X-linked chronic granulomatous disease
2017; American Association for the Advancement of Science; Volume: 9; Issue: 372 Linguagem: Inglês
10.1126/scitranslmed.aah3480
ISSN1946-6242
AutoresSuk See De Ravin, Linhong Li, Xiaolin Wu, Uimook Choi, Cornell Allen, Sherry Koontz, Janet Lee, Narda Theobald-Whiting, Jessica Chu, Mary Garofalo, Colin L. Sweeney, Lela Kardava, Susan Moir, Angelia Viley, Pachai Natarajan, Ling Su, Douglas B. Kuhns, Kol A. Zarember, Madhusudan V. Peshwa, Harry L. Malech,
Tópico(s)Neutrophil, Myeloperoxidase and Oxidative Mechanisms
ResumoCRISPR-mediated gene repair of hematopoietic stem cells from patients with X-linked chronic granulomatous disease resulted in functional human leukocytes in mice after transplantation.
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