Selective and Catalyst-free Oxidation of D-Glucose to D-Glucuronic acid induced by High-Frequency Ultrasound
2017; Nature Portfolio; Volume: 7; Issue: 1 Linguagem: Inglês
10.1038/srep40650
ISSN2045-2322
AutoresPrince Nana Amaniampong, Ayman Karam, Quang Thang Trịnh, Kai Xu, Hajime Hirao, François Jérôme, Grégory Châtel,
Tópico(s)Innovative Microfluidic and Catalytic Techniques Innovation
ResumoAbstract This systematic experimental investigation reveals that high-frequency ultrasound irradiation (550 kHz) induced oxidation of D-glucose to glucuronic acid in excellent yield without assistance of any (bio)catalyst. Oxidation is induced thanks to the in situ production of radical species in water. Experiments show that the dissolved gases play an important role in governing the nature of generated radical species and thus the selectivity for glucuronic acid. Importantly, this process yields glucuronic acid instead of glucuronate salt typically obtained via conventional (bio)catalyst routes, which is of huge interest in respect of downstream processing. Investigations using disaccharides revealed that radicals generated by high frequency ultrasound were also capable of promoting tandem hydrolysis/oxidation reactions.
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