Portal de Periódicos da CAPES

SATB1 plays an oncogenic role in esophageal cancer by up-regulation of FN1 and PDGFRB

2017; Impact Journals LLC; Volume: 8; Issue: 11 Linguagem: Inglês

10.18632/oncotarget.14849

1949-2553

Guiqin Song, Kang Liu, Xiaolin Yang, Bo Mu, Junbao Yang, Lang He, Xin Hu, Qiujiang Li, Yunxia Zhao, Xiaoming Cai, Gang Feng,

RNA modifications and cancer

// Guiqin Song 1, 2, 5, * , Kang Liu 2, 3, * , Xiaolin Yang 1, 2 , Bo Mu 1 , Junbao Yang 1 , Lang He 2, 3 , Xin Hu 3 , Qiujiang Li 4 , Yunxia Zhao 4 , Xiaoming Cai 1 , Gang Feng 2, 3 1 Department of Biology, North Sichuan Medical College, Nanchong, Sichuan, P.R. China 2 Institute of Tissue Engineering and Stem Cells, The Second Clinical Medical College of North Sichuan Medical College, Nanchong Central Hospital, Nanchong, Sichuan, P.R. China 3 Biotherapy Center, Nanchong Central Hospital, Nanchong, Sichuan, P.R. China 4 Clinical college of North Sichuan Medical College, Nanchong, Sichuan, P.R. China 5 State Key Laboratory of Biotherapy, Sichuan University, Chengdu, Sichuan, P.R. China * These authors contributed equally to this work Correspondence to: Xiaoming Cai, email: caixiaoming_sc@163.com Gang Feng, email: fenggangncch@163.com Keywords: SATB1, esophageal cancer, FN1, PDGFRB Received: June 20, 2016 Accepted: January 16, 2017 Published: January 27, 2017 ABSTRACT Esophageal cancer is a highly aggressive malignancy with very poor overall prognosis. Given the strong clinical relevance of SATB1 in esophagus cancer and other cancers suggested by previous studies, the exact function of SATB1 in esophagus cancer development is still unknown. Here we showed that the knockdown of SATB1 in esophageal cancer cell lines diminished the cell proliferation, survival and invasion. Whole genome transcriptome analysis of SATB1 knockdown cells revealed the different gene expression profiles between TE-1 cells and MDA-MB-231 cells. Network analysis and functional experiments further identified FN1 and PDGFRB to be key downstream genes regulated by SATB1 in esophageal cancer cells. Importantly, FN1 and PDGFRB were found to be highly expressed in human esophageal cancer. In summary, we provided the first molecular evidence that SATB1 played an oncogenic role in esophageal cancer by up-regulation of FN1 and PDGFRB.