Produção Nacional
Revisado por pares
Tracking stem cells with superparamagnetic iron oxide nanoparticles: perspectives and considerations
2017; Dove Medical Press; Volume: Volume 12; Linguagem: Inglês
10.2147/ijn.s126530
ISSN1178-2013
AutoresJ. Jasmin, Gustavo Torres de Souza, Ruy A. Louzada, Paulo Henrique Rosado-de-Castro, Rosalia Méndez‐Otero, Antônio Carlos Campos de Carvalho,
Tópico(s)Electrospun Nanofibers in Biomedical Applications
ResumoAbstract: Superparamagnetic iron oxide nanoparticles (SPIONs) have been used for diagnoses in biomedical applications, due to their unique properties and their apparent safety for humans. In general, SPIONs do not seem to produce cell damage, although their long-term in vivo effects continue to be investigated. The possibility of efficiently labeling cells with these magnetic nanoparticles has stimulated their use to noninvasively track cells by magnetic resonance imaging after transplantation. SPIONs are attracting increasing attention and are one of the preferred methods for cell labeling and tracking in preclinical and clinical studies. For clinical protocol approval of magnetic-labeled cell tracking, it is essential to expand our knowledge of the time course of SPIONs after cell incorporation and transplantation. This review focuses on the recent advances in tracking SPION-labeled stem cells, analyzing the possibilities and limitations of their use, not only focusing on myocardial infarction but also discussing other models. Keywords: nanoparticles, superparamagnetic iron oxide nanoparticles, stem cells, cell tracking, in vivo imaging, myocardial infarction
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