Practical Synthesis of Chromeno[2,3‐ b ]indole Skeleton via an Aldehyde Group Insertion/Aromatization Strategy
2017; Wiley; Volume: 12; Issue: 4 Linguagem: Inglês
10.1002/asia.201601681
ISSN1861-4728
AutoresJianming Liu, Na Liu, Yuanyuan Yue, Yanyan Wang, Kaige Chen, Jia Zhang, Shufang Zhao, Kelei Zhuo,
Tópico(s)Catalytic C–H Functionalization Methods
ResumoThe synthesis of chromeno[2,3-b]indole from simple starting materials remains a demanding process. Herein, 2-bromoindole undergoes nucleophilic attack from salicylaldehyde, followed by intramolecular insertion of an aldehyde group and aromatization to generate the desired chromeno[2,3-b]indoles. Moreover, various functional groups were tolerated and a gram-scale synthesis of the product could be achieved under the optimized condition.
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