An ACE in the hole: Unraveling gastrointestinal bleeding in left ventricular assist systemsAn ACE In The Hole: Unraveling Gastrointestinal Bleeding in Left Ventricular Assist Systemsretain-->
2017; Elsevier BV; Volume: 36; Issue: 4 Linguagem: Inglês
10.1016/j.healun.2017.01.1298
ISSN1557-3117
AutoresJames W. Schurr, Craig A. Stevens, Mandeep R. Mehra,
Tópico(s)Transplantation: Methods and Outcomes
ResumoGastrointestinal bleeding (GIB), a highly morbid adverse event of continuous-flow left ventricular assist systems (CF-LVASs), is thought to occur due to low-pulsatile blood flow in such circulatory systems and is a principal hemocompatibility-related adverse outcome.1,2 The reasons for development of GIB are multifactorial and relate to the unique circulatory stress, pro-angiogenic factor expression, and the iatrogenic environment with the use of anti-coagulant and anti-platelet therapy. High shear stress imposed on circulating blood elements leads to loss of high-molecular-weight von Willebrand factor (vWF) multimers producing an acquired von Willebrand syndrome.
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