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Preliminary study of the effects of furosemide on blood pressure during late‐onset pre‐eclampsia in patients with high cardiac output

2016; Elsevier BV; Volume: 136; Issue: 1 Linguagem: Inglês

10.1002/ijgo.12019

1879-3479

Péter Tamás, Eszter Hantosi, Bálint Farkas, Zsolt Ifi, József Betlehem, József Bódis,

Maternal and fetal healthcare

Abstract Objective To examine the effect of furosemide on hypertension and edema in patients with pre‐eclampsia experiencing high cardiac output. Methods The present cohort study enrolled patients with pre‐eclampsia who were admitted to the pregnancy pathology unit of the Department of Obstetrics and Gynecology, University of Pécs, Hungary, between January 1 and December 31, 2015. Eligible patients had singleton pregnancies with no fetal anomalies, high blood volume, visible edema, and a hematocrit concentration below 37 L/L. Blood pressure was measured and impedance cardiography was used to determine cardiac output for all patients before they received a 40‐mg dose of furosemide; after 60 minutes blood pressure and cardiac output were measured again. Results The study enrolled 14 patients. Lower cardiac output ( P =0.002), systolic blood pressure ( P =0.002), and diastolic blood pressure ( P =0.002) were recorded after furosemide administration, with patient heart rates remaining stable. Conclusion The heart‐rate stability suggests that the change of cardiac output was due to a decrease in blood volume. These data suggest that diuretics could be useful in the management of late‐onset pre‐eclampsia, indicating that an increase in water retention could play a role in the development of late‐onset pre‐eclampsia.