Stellate cells drive maturation of the entorhinal-hippocampal circuit
2017; American Association for the Advancement of Science; Volume: 355; Issue: 6330 Linguagem: Inglês
10.1126/science.aai8178
ISSN1095-9203
AutoresFlavio Donato, R. Irene Jacobsen, May‐Britt Moser, Edvard I Moser,
Tópico(s)Neurogenesis and neuroplasticity mechanisms
ResumoThe lights go on in order Grid cells and place cells in the brain function as part of a circuit that helps us figure out where we are in our physical world. Donato et al. examined how that circuit develops in the brains of mice. Expression patterns of doublecortin and parvalbumin revealed that neurons in the circuit mature in the order in which information flows. Maturation of each piece of the circuit depends on excitatory neuronal activity from the preceding portion. Stellate cells, in contrast, follow an endogenous maturation program. The stellate cells are responsible for initiating the circuit's developmental progression. Science , this issue p. eaai8178
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