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Virucidal Activity of World Health Organization–Recommended Formulations Against Enveloped Viruses, Including Zika, Ebola, and Emerging Coronaviruses

2017; Oxford University Press; Volume: 215; Issue: 6 Linguagem: Inglês

10.1093/infdis/jix046

1537-6613

Anindya Siddharta, Stephanie Pfaender, Nathalie J. Vielle, Ronald Dijkman, Martina Friesland, Britta Becker, Jaewon Yang, Michael Engelmann, Daniel Tödt, Marc P. Windisch, Florian H. H. Brill, Joerg Steinmann, Jochen Steinmann, Stephan Becker, Marco P. Alves, Thomas Pietschmann, Markus Eickmann, Volker Thiel, Eike Steinmann,

SARS-CoV-2 and COVID-19 Research

The World Health Organization (WHO) published 2 alcohol-based formulations to be used in healthcare settings and for outbreak-associated infections, but inactivation efficacies of these products have not been determined against (re-)emerging viruses. In this study, we evaluated the virucidal activity of these WHO products in a comparative analysis. Zika virus (ZIKV), Ebola virus (EBOV), severe acute respiratory syndrome coronavirus (SARS-CoV), and Middle East respiratory syndrome coronavirus (MERS-CoV) as (re-)emerging viral pathogens and other enveloped viruses could be efficiently inactivated by both WHO formulations, implicating their use in healthcare systems and viral outbreak situations.