Produção Nacional
Revisado por pares
Adverse drug reactions in high-risk pregnant women: A prospective study
2017; Elsevier BV; Volume: 25; Issue: 7 Linguagem: Inglês
10.1016/j.jsps.2017.01.005
ISSN2213-7475
AutoresAlfredo Dias de Oliveira‐Filho, Antonio Emanuel Soares Vieira, Roberta Cruz da Silva, Sabrina Joany Felizardo Neves, Thiago Antonio Barros Gama, Ryane Vieira Lima, Wlisses Ramon Oliveira, Júlia Maria Gonçalves Dias,
Tópico(s)Pharmaceutical studies and practices
ResumoBecause pregnant women are often excluded from clinical trials, there is still very limited information about the risk and safety of prescription drugs during pregnancy.We aimed to determine the prevalence of Adverse Drug Reactions (ADRs) in high-risk pregnant women after hospital admission. A prospective study was carried out in a teaching maternity hospital in Brazil during six months. Causality of ADRs was assessed through the Naranjo Algorithm and Korean Algorithm for ADR Causality Assessment. Severity of ADRs was assessed using Hartwig's Severity Assessment Scale.The prevalence of ADRs among the 294 inpatients studied was 8.8%. The mean age was 27.14 (±7.5) y.o. Patient's age was related to the presence of ADRs, while the manifestation of these events was not associated with any adverse pregnancy outcome. 75.9% of the ADRs reported in the study were of mild severity and 24.1% were of moderate severity. No ADR was caused by drug-drug interaction; however, a significant increase in blood pressure was observed in all patients using concurrent methyldopa and ferrous sulfate.Overall, ADRs were not common events among high-risk pregnant women and no adverse pregnancy outcomes following these events were observed.
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