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Enantioselective Synthesis of anti-β-Hydroxy-α-amino Esters via an Organocatalyzed Decarboxylative Aldol Reaction

2017; Thieme Medical Publishers (Germany); Volume: 28; Issue: 11 Linguagem: Inglês

10.1055/s-0036-1588141

1437-2096

Yoshiji Takemoto, Taryn L. March, Akihiro Murata, Yusuke Kobayashi,

Chemical Synthesis and Analysis

The first enantioselective decarboxylative aldol addition with α-amido-substituted malonic acid half oxyesters (MAHOs) is described. The combined use of a newly designed bifunctional sulfonamide catalyst with pentafluorobenzoic acid as an additive afforded the β-hydroxy-α-amino acid derivatives in moderate to high yields and with high enantioselectivities.