A Rapid, Extensive, and Transient Transcriptional Response to Estrogen Signaling in Breast Cancer Cells
2011; Cell Press; Volume: 145; Issue: 7 Linguagem: Inglês
10.1016/j.cell.2011.06.003
ISSN1097-4172
AutoresNasun Hah, Charles G. Danko, Leighton J. Core, Joshua J. Waterfall, Adam Siepel, John T. Lis, W. Lee Kraus,
Tópico(s)Cancer-related molecular mechanisms research
Resumo(Cell 145, 622-634; May 13, 2011) In the color-coded key of Figure S1B in the above article, “S” and “G0/G1” were inadvertently switched. A corrected version of Figure S1 is shown below. Approximately 60%–70% of the cells in each condition are in G0/G1. A Rapid, Extensive, and Transient Transcriptional Response to Estrogen Signaling in Breast Cancer CellsHah et al.CellMay 5, 2011In BriefWe report the immediate effects of estrogen signaling on the transcriptome of breast cancer cells using global run-on and sequencing (GRO-seq). The data were analyzed using a new bioinformatic approach that allowed us to identify transcripts directly from the GRO-seq data. We found that estrogen signaling directly regulates a strikingly large fraction of the transcriptome in a rapid, robust, and unexpectedly transient manner. In addition to protein-coding genes, estrogen regulates the distribution and activity of all three RNA polymerases and virtually every class of noncoding RNA that has been described to date. Full-Text PDF Open Archive
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