Antibiotics from basidiomycetes XLI. Clavicoronic acid, a novel inhibitor of reverse transcriptases from Clavicorona pyxidata (Pers. ex Fr.) Doty.
1992; Springer Nature; Volume: 45; Issue: 1 Linguagem: Inglês
10.7164/antibiotics.45.29
ISSN1881-1469
AutoresGerhard Erkel, Timm Anke, Alberto Giménez, Wölfgang Steglich,
Tópico(s)Plant and Fungal Interactions Research
ResumoA novel inhibitor of RNA-directed DNA-polymerases was isolated from fermentations of Clavicorona pyxidata. Its structure was elucidated by spectroscopic methods. Clavicoronic acid (1) is a noncompetitive inhibitor of avian myeloblastosis virus (Ki 130 μM) and Moloney murine leukemia virus (Ki 68μM) reverse transcriptases. In permeabilized cells and isolated nucleic DNA- and RNA-synthesis are not affected. Clavicoronic acid markedly inhibits the multiplication of vesicular stomatitis virus in baby hamster kidney cells by interfering with this virus's RNA-directed RNA-polymerase. 1 exhibits no cytotoxic and very weak antimicrobial activities.
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