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Global motor unit number index sum score for assessing the loss of lower motor neurons in amyotrophic lateral sclerosis

2017; Wiley; Volume: 56; Issue: 2 Linguagem: Inglês

10.1002/mus.25595

1097-4598

Stéphan Grimaldi, Lauréline Duprat, Aude‐Marie Grapperon, Annie Verschueren, Émilien Delmont, Shahram Attarian,

Parkinson's Disease Mechanisms and Treatments

Muscle & NerveVolume 56, Issue 2 p. 202-206 Clinical Research Global motor unit number index sum score for assessing the loss of lower motor neurons in amyotrophic lateral sclerosis Stephan Grimaldi MD, Stephan Grimaldi MD Reference Center for Neuromuscular Diseases and ALS, APHM, University Hospital of Marseille/Timone University Hospital, 264 rue Saint Pierre, 13005 Marseille, France Stephan Grimaldi and Lauréline Duprat contributed equally to this work.Search for more papers by this authorLauréline Duprat MD, Lauréline Duprat MD Reference Center for Neuromuscular Diseases and ALS, APHM, University Hospital of Marseille/Timone University Hospital, 264 rue Saint Pierre, 13005 Marseille, France Stephan Grimaldi and Lauréline Duprat contributed equally to this work.Search for more papers by this authorAude-Marie Grapperon MD, Corresponding Author Aude-Marie Grapperon MD aude-marie.grapperon@ap-hm.fr Reference Center for Neuromuscular Diseases and ALS, APHM, University Hospital of Marseille/Timone University Hospital, 264 rue Saint Pierre, 13005 Marseille, FranceCorrespondence to: A.-M. Grapperon; e-mail: aude-marie.grapperon@ap-hm.frSearch for more papers by this authorAnnie Verschueren MD, Annie Verschueren MD Reference Center for Neuromuscular Diseases and ALS, APHM, University Hospital of Marseille/Timone University Hospital, 264 rue Saint Pierre, 13005 Marseille, FranceSearch for more papers by this authorEmilien Delmont MD, PhD, Emilien Delmont MD, PhD Reference Center for Neuromuscular Diseases and ALS, APHM, University Hospital of Marseille/Timone University Hospital, 264 rue Saint Pierre, 13005 Marseille, FranceSearch for more papers by this authorShahram Attarian MD, PhD, Shahram Attarian MD, PhD Reference Center for Neuromuscular Diseases and ALS, APHM, University Hospital of Marseille/Timone University Hospital, 264 rue Saint Pierre, 13005 Marseille, France Aix Marseille University, INSERM, GMGF, Marseille, FranceSearch for more papers by this author Stephan Grimaldi MD, Stephan Grimaldi MD Reference Center for Neuromuscular Diseases and ALS, APHM, University Hospital of Marseille/Timone University Hospital, 264 rue Saint Pierre, 13005 Marseille, France Stephan Grimaldi and Lauréline Duprat contributed equally to this work.Search for more papers by this authorLauréline Duprat MD, Lauréline Duprat MD Reference Center for Neuromuscular Diseases and ALS, APHM, University Hospital of Marseille/Timone University Hospital, 264 rue Saint Pierre, 13005 Marseille, France Stephan Grimaldi and Lauréline Duprat contributed equally to this work.Search for more papers by this authorAude-Marie Grapperon MD, Corresponding Author Aude-Marie Grapperon MD aude-marie.grapperon@ap-hm.fr Reference Center for Neuromuscular Diseases and ALS, APHM, University Hospital of Marseille/Timone University Hospital, 264 rue Saint Pierre, 13005 Marseille, FranceCorrespondence to: A.-M. Grapperon; e-mail: aude-marie.grapperon@ap-hm.frSearch for more papers by this authorAnnie Verschueren MD, Annie Verschueren MD Reference Center for Neuromuscular Diseases and ALS, APHM, University Hospital of Marseille/Timone University Hospital, 264 rue Saint Pierre, 13005 Marseille, FranceSearch for more papers by this authorEmilien Delmont MD, PhD, Emilien Delmont MD, PhD Reference Center for Neuromuscular Diseases and ALS, APHM, University Hospital of Marseille/Timone University Hospital, 264 rue Saint Pierre, 13005 Marseille, FranceSearch for more papers by this authorShahram Attarian MD, PhD, Shahram Attarian MD, PhD Reference Center for Neuromuscular Diseases and ALS, APHM, University Hospital of Marseille/Timone University Hospital, 264 rue Saint Pierre, 13005 Marseille, France Aix Marseille University, INSERM, GMGF, Marseille, FranceSearch for more papers by this author First published: 06 February 2017 https://doi.org/10.1002/mus.25595Citations: 19 Conflicts of Interest: : None of the authors have any conflicts of interest to disclose. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat ABSTRACT Introduction We propose a motor unit number index (MUNIX) global sum score in amyotrophic lateral sclerosis (ALS) to estimate the loss of functional motor units. Methods MUNIX was assessed for 18 ALS patients and 17 healthy controls in 7 muscles: the abductor pollicis brevis (APB), abductor digiti minimi (ADM), tibialis anterior (TA), deltoid, trapezius, submental complex, and orbicularis oris. Results MUNIX was significantly lower in ALS patients than in healthy controls for the APB, ADM, TA, and trapezius muscles. The MUNIX sum score of 4 muscles (ADM + APB + trapezius + TA) was lower in ALS patients (P = 0.01) and was correlated with clinical scores. Discussion The global MUNIX sum score proposed in this study estimates the loss of lower motor neurons in several body regions, including the trapezius, and is correlated with clinical impairment in ALS patients. Muscle Nerve 56: 202–206, 2017 Citing Literature Volume56, Issue2August 2017Pages 202-206 RelatedInformation