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D-α-tocopheryl polyethylene glycol 1000 succinate functionalized nanographene oxide for cancer therapy

2017; Future Medicine; Volume: 12; Issue: 5 Linguagem: Inglês

10.2217/nnm-2016-0384

1748-6963

Duarte de Melo‐Diogo, Cleide Pais‐Silva, Elisabete C. Costa, Ricardo O. Louro, Ilídio J. Correia,

Carbon and Quantum Dots Applications

To evaluate the therapeutic capacity of D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS)-functionalized nanographene oxide (nGO) in breast cancer cells.TPGS-functionalized nGO-based materials were obtained through two different approaches: a simple sonication method and a one-pot hydrothermal treatment.TPGS coating successfully improved the stability of the nGO-based materials. The nanomaterials that underwent the hydrothermal procedure generated a 1.4- to 1.6-fold higher temperature variation under near infrared laser irradiation than those prepared only by sonication. In vitro, the TPGS/nGO derivatives reduced breast cancer cells' viability and had an insignificant effect on healthy cells. Furthermore, the combined application of TPGS/nGO derivatives and near infrared light generated an improved therapeutic effect.TPGS/nGO derivatives are promising materials for breast cancer phototherapy.