Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Protein as a Marker for Disease Severity in Patients With Acute Infection
2016; Oxford University Press; Volume: 3; Issue: suppl_1 Linguagem: Inglês
10.1093/ofid/ofw172.103
ISSN2328-8957
AutoresKfir Oved, Asi Cohen, Olga Boico, Roy Navon, Tom Friedman, Liat Etshtein, Ellen Bamberger, Ester Pri-Or, Tanya M. Gottlieb, Meital Paz, Isaac Srugo, Irina Chistyakov, Adi Klein, Israel Potasman, Eran Eden,
Tópico(s)Drug-Induced Hepatotoxicity and Protection
ResumoBackground.Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor family implicated in programmed cell death.We recently demonstrated that TRAIL can serve as a useful biomarker for distinguishing between bacterial and viral infections when computationally combined with C-reactive protein and IP-10.Here, we report that low TRAIL concentration in the blood is significantly correlated with poor patient prognosis and higher disease severity.Methods.We studied 765 hospitalized and emergency department patients with acute infection and controls with no apparent infection, prospectively recruited
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