Biological Activities in Animal Models.
2003; Springer Nature; Volume: 56; Issue: 2 Linguagem: Inglês
10.7164/antibiotics.56.80
ISSN1881-1469
AutoresHiroaki Mori, Fumie Abe, Satoko Furukawa, Shigetada Furukawa, Fumihiko Sakai, Motohiro Hino, Takashi Fujii,
Tópico(s)Chemical Synthesis and Analysis
ResumoFR235222, a novel immunosuppressant which possesses potent inhibitory effects on the activity of mammalian histone deacetylases (HDACs), has been isolated from the fermentation broth of a fungus, Acremonium sp. No. 27082. FR235222 exhibited marked immunosuppressive effects on mouse ex vivo splenic T-lymphocyte proliferation, mouse delayed type hypersensitivity (DTH) response, rat adjuvant-induced arthritis (AA) and rat heterotopic cardiac transplantation. These results showed potential clinical use of this compound as a new type immunosuppressant in the fields of autoimmune diseases and organ transplantations.
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