Feasibility of accelerated simultaneous multislice diffusion‐weighted MRI of the prostate
2017; Wiley; Volume: 46; Issue: 5 Linguagem: Inglês
10.1002/jmri.25665
ISSN1522-2586
AutoresJakob Weiß, Petros Martirosian, Jana Taron, Mohamed I. A. Othman, Thomas Kuestner, Michael Erb, Jens Bedke, Fabian Bamberg, Konstantin Nikolaou, Mike Notohamiprodjo,
Tópico(s)Prostate Cancer Diagnosis and Treatment
ResumoPurpose To assess the feasibility of simultaneous multislice (SMS) single‐shot echo‐planar‐imaging (EPI) for accelerated diffusion‐weighted imaging (DWI) of the prostate. Materials and Methods For phantom measurements a dedicated DWI phantom with different sucrose concentrations was used. In addition, 10 volunteers and 16 patients with suspected prostate cancer were examined for in vivo measurements. All examinations were performed with a 3T magnetic resonance imaging (MRI) system. A prototype simultaneous multislice EPI sequence (DW‐EPI SMS ; acquisition time 3:14 min) was acquired and compared to a single‐shot EPI sequence (DW‐EPI SS ; acquisition time 6:12 min) serving as a standard of reference. Different image quality parameters of EPI SMS were assessed qualitatively (overall image quality, anatomic differentiability, lesion conspicuity, image noise, distortion; two independent readers; 5‐point Likert‐scale [5 = excellent]) and quantitatively (ADC‐values by calculating interclass correlation [ICC] and Bland–Altman limits of agreement [LoA] as measures for reproducibility) and compared to DW‐EPI SS . Results DW‐EPI SMS allowed for a substantially reduced acquisition time as compared to DW‐EPI SS (˜50%). Bland–Altman plots revealed robust measurement repeatability for DW‐EPI SMS in the phantom study. Overall image quality did not significantly differ between DW‐EPI SMS and DW‐EPI SS (b1500 images P = 0.5; ADC maps P = 0.7). Only in b1500 DW images was subjective image noise rated significantly higher in DW‐EPI SS than in DW‐EPI SMS ( P = 0.006). Quantitative analysis of ADC‐values revealed not significant differences between DW‐EPI SMS and DW‐EPI SS ( P = 0.7) and high measures for reproducibility ICC ≥0.96. Conclusion Simultaneous multislice DWI is feasible for accelerated prostate MRI allowing for a substantially reduced examination time with similar image quality and ADC‐values as compared to a standard of reference DWI sequence. Level of Evidence: 3 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2017;46:1507–1515.
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