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Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice

2017; American Association for the Advancement of Science; Volume: 355; Issue: 6326 Linguagem: Inglês

10.1126/science.aal0092

1095-9203

Pete A. Williams, Jeffrey M. Harder, Nicole E. Foxworth, Kelly E. Cochran, Vivek M. Philip, Vittorio Porciatti, Oliver Smithies, Simon W. M. John,

Retinopathy of Prematurity Studies

Glaucomas are neurodegenerative diseases that cause vision loss, especially in the elderly. The mechanisms initiating glaucoma and driving neuronal vulnerability during normal aging are unknown. Studying glaucoma-prone mice, we show that mitochondrial abnormalities are an early driver of neuronal dysfunction, occurring before detectable degeneration. Retinal levels of nicotinamide adenine dinucleotide (NAD