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Changing trends in serotypes of S. pneumoniae isolates causing invasive and non-invasive diseases in unvaccinated population in Mexico (2000-2014)

2017; Elsevier BV; Volume: 58; Linguagem: Inglês

10.1016/j.ijid.2017.02.005

1878-3511

María Noemí Carnalla-Barajas, Araceli Soto‐Noguerón, Miguel Ángel Sánchez-Alemán, Fortino Solórzano‐Santos, María Elena Velázquez-Meza, Gabriela Echániz-Avilés, Francisco Márquez-Díaz, Lucila Martínez‐Medina, María Elizabeth Olvera-Herrera, Marı́a Guadalupe Miranda-Novales, Martha Camacho-Velázquez, José Guillermo Vásquez-Rosales, Rosario Vázquez-Larios, Eduardo Rivera-Martínez, Ana María del Rocío Hernández-Dueñas, Briceida López‐Martínez, Sarbelio Moreno-Espinoza, Ernesto Calderón-Jaimes, Yolanda Jiménez-Tapia, José Luis Arredondo-Garcı́a, Mercedes Macías-Parra, Patricia Arzate-Barbosa, Napoleón González Saldaña, José Sifuentes‐Osornio, Alfredo Ponce‐de‐León, Ana Lilia Rolón-Montes de, Rosa Areli Martínez‐Gamboa, Patricia Volkow-Fernández, Patricia Cornejo‐Juárez, José Manuel Feliciano-Guzmán, Ismelda López-Ovilla, Juan Manuel Barajas-Magallón, Jorge Vázquez-Narváez, Alejandra Cendejas-Amezcua, María del Rosario Magaña-Miranda, Andrés Flores Santos, Martín Magaña-Aquino, Antonio Luévanos-Velázquez, Rayo Morfín‐Otero, Eduardo Rodríguez-Noriega, Sergio Esparza-Ahumada, Guadalupe Atilano-Durán, Norma de la Re-Montaño, Martha Anchondo-Martínez, Jesús Contreras-Soto, Ana Dolores Quintero-Grijalva, Jacobo Ayala-Aguilar, Claudia Elena Guajardo-Lara, Elvira Garza‐González, oaquín Rincón-Zuno, Domingo Sánchez-Francia, Verónica Andrade-Almaraz, Reyna Edith Corte-Rojas, María del Socorro Gutierrez-Rodríguez, Socorro Azarell Anzurez-Gutiérrez, Juan Luis Mosqueda-Gómez, Mariana Gil-Veloz, Javier Castellanos-Martínez, Juan Carlos Tinoco-Fávila, Lorena Salcido-Gutiérrez, Rosalía Jarillo-Medina, Jessica Paola-Purizaca Bazán, Dinora Aguilar-Escobar, Ana Rosa Méndez-Cruz, Leova Pacheco-Gil, Edgardo S. Acevedo-Casarrubias, Alma Rosa González-Hernandez, María del Carmen Alvarez Molina, Manuel Ibarra-Muñiz, Paul Mora-Dominguez,

Influenza Virus Research Studies

Introduction of pneumococcal conjugate vaccines (PCV) targeted against a limited number of serotypes substantially decreased invasive (IPD) and non-invasive pneumococcal diseases (NIPD) but it was accompanied by non-vaccine type replacement disease. After 9 years of introduction of PCV in Mexico, we analyze the evidence of the indirect effects on IPD and NIPD serotype distribution among groups not targeted to receive the vaccine.From January 2000 to December 2014, pneumococcal strains isolated from IPD and NIPD cases from patients ≥5 years of age from participant hospitals of the SIREVA II (Sistema Regional de Vacunas) network were serotyped. A regression analysis was performed considering year and proportion of serotypes included in the different vaccine formulations (PCV7, PCV10 and PCV13). The slope was obtained for each regression line and their correspondent p-value. The proportion of each serotype in the pre-PCV7 and post-PCV7 periods was evaluated by χ2 test.From a total of 1147 pneumococcal strains recovered, 570 corresponded to the pre-PCV7 and 577 to the post-PCV7 periods. The proportion of vaccine serotypes included in the three PCV formulations decreased by 2.4, 2.6 and 1.3%, respectively per year during the study period. A significant increase of serotype 19A was observed in the post-vaccine period in all age groups.A percentage of annual decline of serotypes causing IPD and NIPD included in PCV was detected among groups not targeted to receive the vaccine, probably due to herd effect. Considering pneumococcal serotype distribution is a dynamic process, we highlight the importance of surveillance programs.