Manganese-catalyzed allylation via sequential C–H and C–C/C–Het bond activation
2017; Royal Society of Chemistry; Volume: 8; Issue: 5 Linguagem: Inglês
10.1039/c7sc00230k
ISSN2041-6539
AutoresQingquan Lu, Felix J. R. Klauck, Frank Glorius,
Tópico(s)Asymmetric Hydrogenation and Catalysis
ResumoManganese-catalyzed sequential C-H and C-C/C-Het bond activation to synthesize allylic alcohols, allylated arenes, functionalized cyclopentenes and skipped dienes is reported. This protocol can be readily scaled up and various coupling partners are applied in manganese catalysis for the first time. Moreover, manganese-catalyzed alkenyl C(sp2)-H activation is also shown. Complimentary to the standard solution-based protocols, these reactions also proceed efficiently under neat conditions, which is unprecedented for abundant metal catalyzed C-H activation reactions.
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