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Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases

2017; American Medical Association; Volume: 3; Issue: 5 Linguagem: Inglês

10.1001/jamaoncol.2016.5945

2374-2445

Philip Haycock, Stephen Burgess, Aayah Nounu, Jie Zheng, George N. Okoli, Jack Bowden, Kaitlin H. Wade, Nicholas J. Timpson, David M. Evans, Peter Willeit, Abraham Aviv, Tom R. Gaunt, Gibran Hemani, Massimo Mangino, Hayley Ellis, Kathreena M. Kurian, Karen A. Pooley, Rosalind A. Eeles, Jeffrey E. Lee, Shenying Fang, Wei V. Chen, Matthew H. Law, Lisa Bowdler, Mark M. Iles, Qiong Yang, Bradford B. Worrall, Hugh S. Markus, Rayjean J. Hung, Chris Amos, Amanda B. Spurdle, Deborah J. Thompson, Tracy A. O’Mara, Brian M. Wolpin, Laufey T. Ámundadóttir, Rachael Z. Stolzenberg‐Solomon, Antonia Trichopoulou, N. Charlotte Onland‐Moret, Eiliv Lund, Eric J. Duell, Federico Canzian, Gianluca Severi, Kim Overvad, Marc J. Gunter, ­Rosario ­Tumino, Ulrika Svenson, André van Rij, Annette F. Baas, Matthew J. Bown, Nilesh J. Samani, Femke N.G. van t’Hof, Gerard Tromp, Gregory T. Jones, Helena Kuivaniemi, James R. Elmore, Mattias Johansson, James McKay, Ghislaine Scélo, Robert Carreras‐Torres, Valérie Gaborieau, Paul Brennan, Paige M. Bracci, Rachel Ε. Neale, Sara H. Olson, Steven Gallinger, Donghui Li, Gloria M. Petersen, Harvey A. Risch, Alison P. Klein, Jiali Han, Christian C. Abnet, Neal D. Freedman, Philip R. Taylor, John M. Maris, Katja K.H. Aben, Lambertus A. Kiemeney, Sita H. Vermeulen, John K. Wiencke, Kyle M. Walsh, Margaret Wrensch, Terri Rice, Clare Turnbull, Kevin Litchfield, Lavinia Paternoster, Marie Standl, Gonçalo R. Abecasis, John Paul SanGiovanni, Yong Li, Vladan Mijatovic, Yadav Sapkota, Siew‐Kee Low, Krina T. Zondervan, Grant W. Montgomery, Dale R. Nyholt, David A. van Heel, Karen A. Hunt, Dan E. Arking, Foram N. Ashar, Nona Sotoodehnia, Daniel Woo, Jonathan Rosand, Mary E. Comeau, W. Mark Brown, Edwin K. Silverman, John E. Hokanson, Michael H. Cho, Jennie Hui, Manuel A. R. Ferreira, Philip J. Thompson, Alanna C. Morrison, Janine F. Felix, Nicholas L. Smith, Angela M. Christiano, Lynn Petukhova, Regina C. Betz, Xing Fan, Xuejun Zhang, Caihong Zhu, Carl D. Langefeld, Susan D. Thompson, Feijie Wang, Lin Xu, David A. Schwartz, Tasha E. Fingerlin, Jerome I. Rotter, Mary Frances Cotch, Richard A. Jensen, Matthias Munz, Henrik Dommisch, Arne S. Schäefer, Fang Han, Hanna M. Ollila, Ryan P. Hillary, Omar Albagha, Stuart H. Ralston, Chenjie Zeng, Wei Zheng, Xiao-Ou Shu, André Reis, Steffen Uebe, Ulrike Hüffmeier, Yoshiya Kawamura, Takeshi Otowa, Takehiko Sasaki, Martin L. Hibberd, Sonia Dávila, Gang Xie, Katherine A. Siminovitch, Jin‐Xin Bei, Yi‐Xin Zeng, Asta Försti, Bowang Chen, Stefano Landi, Andre Franke, Annegret Fischer, David Ellinghaus, Carlos Flores, Imre Noth, Shwu‐Fan Ma, Jia Nee Foo, Jianjun Liu, Jong‐Won Kim, David G. Cox, Olivier Delattre, Olivier Mirabeau, Christine F. Skibola, Clara Sze-Man Tang, Mercè Garcia-Barceló, Kai‐Ping Chang, Wen-Hui Su, Yu‐Sun Chang, Nicholas G. Martin, Scott D. Gordon, Tracey Wade, Chaeyoung Lee, Michiaki Kubo, Pei-Chieng Cha, Yusuke Nakamura, Daniel Levy, Masayuki Kimura, Shih‐Jen Hwang, S. E. Hunt, Tim D. Spector, Nicole Soranzo, Ani Manichaikul, R. Graham Barr, Bratati Kahali, Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Ching‐Yu Cheng, Jost B. Jonas, Tien Yin Wong, Isabella Fogh, Kuang Lin, John Powell, Kenneth Rice, Caroline L. Relton, Richard M. Martin, George Davey Smith,

Health, Environment, Cognitive Aging

The causal direction and magnitude of the association between telomere length and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility of observational studies to confounding and reverse causation.