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BIBTEX RIS

Emergence of a novel subclade of influenza A(H3N2) virus in London, December 2016 to January 2017

2017; European Centre for Disease Prevention and Control; Volume: 22; Issue: 8 Linguagem: Inglês

10.2807/1560-7917.es.2017.22.8.30466

ISSN

1560-7917

Autores

Heli Harvala, Dan Frampton, Paul R. Grant, Jade Raffle, R. Bridget Ferns, Zisis Kozlakidis, Paul Kellam, Deenan Pillay, Andrew Hayward, Eleni Nastouli,

Tópico(s)

RNA and protein synthesis mechanisms

Resumo

We report the molecular investigations of a large influenza A(H3N2) outbreak, in a season characterised by sharp increase in influenza admissions since December 2016. Analysis of haemagglutinin (HA) sequences demonstrated co-circulation of multiple clades (3C.3a, 3C.2a and 3C.2a1). Most variants fell into a novel subclade (proposed as 3C.2a2); they possessed four unique amino acid substitutions in the HA protein and loss of a potential glycosylation site. These changes potentially modify the H3N2 strain antigenicity.

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