Produção Nacional
Revisado por pares
Tumor volume as an independent predictive factor of worse survival in patients with oral cavity squamous cell carcinoma
2017; Wiley; Volume: 39; Issue: 5 Linguagem: Inglês
10.1002/hed.24714
ISSN1097-0347
AutoresChin Shien Lin, André Bandiera de Oliveira Santos, Evandro Lima e Silva, Leandro Luongo de Matos, Raquel Ajub Moysés, Marco Aurélio Vamondes Kulcsar, Fábio Roberto Pinto, Lenine Garcia Brandão, Cláudio Roberto Cernea,
Tópico(s)Cholangiocarcinoma and Gallbladder Cancer Studies
ResumoABSTRACT Background The purpose of the present study was to investigate the role of tumor volume in the prognosis of patients with oral cavity squamous cell carcinoma (SCC). Methods One hundred twenty‐three patients with T4a oral cavity SCCs underwent surgical treatment. The volumes of the primary cancer were calculated by the multiplication of 3 macroscopic dimensions of the surgical specimen and related to recurrence and death. Results There were 54 recurrences (43.9%) and 75 deaths (60.9%). The mean tumor volume among the patients living without disease during the follow‐up period was 28.2 cc, compared to 88.2 cc for patients living with disease, and to 78.9 cc for patients who died of the disease ( p < .001). Multivariate analyses showed that volume and perineural invasion were independent factors for recurrence, whereas volume and lymph node metastasis were independent factors for death. Conclusion Among patients who already have advanced cancers, tumor volume can significantly impact their prognoses. © 2017 Wiley Periodicals, Inc. Head Neck 39: 960–964, 2017
Referência(s)