Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Role of microbial biofilms in the maintenance of oral health and in the development of dental caries and periodontal diseases. Consensus report of group 1 of the Joint EFP/ORCA workshop on the boundaries between caries and periodontal disease

2017; Wiley; Volume: 44; Issue: S18 Linguagem: Inglês

10.1111/jcpe.12682

1600-051X

Mariano Sanz, D. Beighton, Michael A. Curtis, Jaime Aparecido Cury, Irene Dige, Henrik Dommisch, R.P. Ellwood, Rodrigo A. Giacaman, David Herrera, Mark C. Herzberg, Eija Könönen, Philip D. Marsh, Joerg Meyle, Álex Mira, Ana Molina, Andrea Mombelli, Marc Quirynen, Eric C. Reynolds, Lior Shapira, Egija Zaura,

Salivary Gland Disorders and Functions

The scope of this working group was to review (1) ecological interactions at the dental biofilm in health and disease, (2) the role of microbial communities in the pathogenesis of periodontitis and caries, and (3) the innate host response in caries and periodontal diseases.A health-associated biofilm includes genera such as Neisseria, Streptococcus, Actinomyces, Veillonella and Granulicatella. Microorganisms associated with both caries and periodontal diseases are metabolically highly specialized and organized as multispecies microbial biofilms. Progression of these diseases involves multiple microbial interactions driven by different stressors. In caries, the exposure of dental biofilms to dietary sugars and their fermentation to organic acids results in increasing proportions of acidogenic and aciduric species. In gingivitis, plaque accumulation at the gingival margin leads to inflammation and increasing proportions of proteolytic and often obligately anaerobic species. The natural mucosal barriers and saliva are the main innate defence mechanisms against soft tissue bacterial invasion. Similarly, enamel and dentin are important hard tissue barriers to the caries process. Given that the present state of knowledge suggests that the aetiologies of caries and periodontal diseases are mutually independent, the elements of innate immunity that appear to contribute to resistance to both are somewhat coincidental.