Portal de Periódicos da CAPES

Paraoxonase 1 gene polymorphisms are associated with an increased risk of breast cancer in a population of Chinese women

2017; Impact Journals LLC; Volume: 8; Issue: 15 Linguagem: Inglês

10.18632/oncotarget.15911

1949-2553

Junrong Wu, Min Fang, Xiaoping Zhou, Bo Zhu, Zhi Yang,

Childhood Cancer Survivors' Quality of Life

// Junrong Wu 1, * , Min Fang 1, * , Xiaoping Zhou 2 , Bo Zhu 1 , Zhi Yang 3 1 Department of Clinical Laboratory, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China 2 Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, 530022, Guangxi, China 3 Department of Nuclear Medicine, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China * These authors have contributed equally to this work Correspondence to: Bo Zhu, email: wjr4455321@163.com Zhi Yang, email: yangzhi1985@163.com Keywords: breast cancer, paraoxonase 1, gene polymorphisms, menopausal Received: July 28, 2016 Accepted: February 15, 2017 Published: March 06, 2017 ABSTRACT In this study, we explored associations between paraoxonase 1 (PON1) L55M and Q192R gene polymorphisms and the risk of breast cancer in 365 female breast cancer patients and 378 healthy controls from the Guangxi region of southern China. The LM heterozygous and MM homozygous genotypes, as well as M carrier status and M alleles, were associated with an increased risk of breast cancer. In addition, the M allele was associated with postmenopausal status and increased nodal involvement. In contrast, none of the Q192R genotypes or alleles were associated with a change in breast cancer risk, or with any of the clinicopathological parameters. These results indicate that PON1 L55M genetic polymorphisms may be associated with the risk of breast cancer and could potentially serve as useful genetic markers for tumor prognosis in some populations of Chinese women.