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BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer

2017; American Association for Cancer Research; Volume: 77; Issue: 11 Linguagem: Inglês

10.1158/0008-5472.can-16-2568

1538-7445

Hermela Shimelis, Romy L.S. Mesman, Catharina Von Nicolai, Åsa Ehlén, Lucia Guidugli, Charlotte Martin, Fabienne M.G.R. Calléja, Huong Meeks, Emily Hallberg, Jamie Hinton, Jenna Lilyquist, Chunling Hu, Cora M. Aalfs, Kristiina Aittomäki, Irene L. Andrulis, Hoda Anton‐Culver, Volker Arndt, Matthias W. Beckmann, Javier Benı́tez, Natalia Bogdanova, Stig E. Bojesen, Manjeet K. Bolla, Anne‐Lise Børresen‐Dale, Hiltrud Brauch, Paul Brennan, Hermann Brenner, Annegien Broeks, Barbara Brouwers, Thomas Brüning, Barbara Burwinkel, Jenny Chang‐Claude, Georgia Chenevix‐Trench, Ching‐Yu Cheng, Ji‐Yeob Choi, J. Margriet Collée, Angela Cox, Simon S. Cross, Kamila Czene, Hatef Darabi, Joe Dennis, Thilo Dörk, Isabel dos‐Santos‐Silva, Alison M. Dunning, Peter A. Fasching, Jonine D. Figueroa, Henrik Flyger, Montserrat García‐Closas, Graham G. Giles, Gord Glendon, Pascal Guénel, Christopher A. Haiman, Per Hall, Ute Hamann, Mikael Hartman, Frans B.L. Hogervorst, Antoinette Hollestelle, John L. Hopper, Hidemi Ito, Anna Jakubowska, Daehee Kang, Veli‐Matti Kosma, Vessela N. Kristensen, Kah-Nyin Lai, Diether Lambrechts, Loı̈c Le Marchand, Jingmei Li, Annika Lindblom, Artitaya Lophatananon, Jan Lubiński, Eva Macháčková, Graham J. Mann, Sara Margolin, Frederik Marmé, Keitaro Matsuo, Hui Miao, Kyriaki Michailidou, Roger L. Milne, Kenneth Muir, Susan L. Neuhausen, Heli Nevanlinna, Janet E. Olson, Curtis Olswold, Jan J.C. Oosterwijk, Ana Osório, Paolo Peterlongo, Julian Peto, Paul D.P. Pharoah, Katri Pylkäs, Paolo Radice, Muhammad Usman Rashid, Valerie Rhenius, Anja Rudolph, Suleeporn Sangrajrang, Elinor J. Sawyer, Marjanka K. Schmidt, Minouk J. Schoemaker, Caroline Seynaeve, Mitul Shah, Chen‐Yang Shen, Martha J. Shrubsole, Xiao‐Ou Shu, Susan Slager, Melissa C. Southey, Daniel O. Stram, Anthony J. Swerdlow, Soo‐Hwang Teo, Ian Tomlinson, Diana Torres, Thérèse Truong, Christi J. van Asperen, Lizet E. van der Kolk, Sophia Wang, Robert Winqvist, Anna H. Wu, Jyh‐Cherng Yu, Wei Zheng, Ying Zheng, Jennifer Leary, Logan C. Walker, Lenka Foretová, Florentia Fostira, Kathleen Claes, Liliana Varesco, Setareh Moghadasi, Douglas F. Easton, Amanda B. Spurdle, Peter Devilee, Harry Vrieling, Álvaro N.A. Monteiro, David E. Goldgar, Aura Carreira, Maaike P.G. Vreeswijk, Fergus J. Couch,

Nutrition, Genetics, and Disease

Breast cancer risks conferred by many germline missense variants in the