Portal de Periódicos da CAPES

O 2 ⋅− and H 2 O 2 -Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate

2017; Cell Press; Volume: 31; Issue: 4 Linguagem: Inglês

10.1016/j.ccell.2017.02.018

1878-3686

Joshua D. Schoenfeld, Zita A. Sibenaller, Kranti A. Mapuskar, Brett A. Wagner, Kimberly Cramer-Morales, Muhammad Furqan, Sonia Sandhu, Thomas Carlisle, Mark C. Smith, Taher Abu Hejleh, Daniel Berg, Jun Zhang, John Keech, Kalpaj R. Parekh, Sudershan K. Bhatia, Varun Monga, Kellie L. Bodeker, Logan Ahmann, Sandy Vollstedt, Heather A. Brown, Erin P. Shanahan Kauffman, Mary E. Schall, R.J. Hohl, Gerald H. Clamon, Jeremy D.W. Greenlee, Matthew A. Howard, Michael K. Schultz, Bruce A. Smith, Dennis P. Riley, Frederick E. Domann, Joseph J. Cullen, Garry R. Buettner, John M. Buatti, Douglas R. Spitz, Bryan G. Allen,

Vitamin D Research Studies

Pharmacological ascorbate has been proposed as a potential anti-cancer agent when combined with radiation and chemotherapy. The anti-cancer effects of ascorbate are hypothesized to involve the autoxidation of ascorbate leading to increased steady-state levels of H