Portal de Periódicos da CAPES

Clinical significance of the correlation between PLCE 1 and PRKCA in esophageal inflammation and esophageal carcinoma

2017; Impact Journals LLC; Volume: 8; Issue: 20 Linguagem: Inglês

10.18632/oncotarget.16635

1949-2553

Yongchen Guo, Yonghua Bao, Ming Ma, Shanshan Zhang, Yongmeng Zhang, Ming Yuan, Bing Liu, Yiqiong Yang, Wen Cui, Emmanuel Ansong, Huali Dong, Virgilia Macias, Wancai Yang,

Lymphoma Diagnosis and Treatment

// Yongchen Guo 1, * , Yonghua Bao 1, * , Ming Ma 2 , Shanshan Zhang 3 , Yongmeng Zhang 3 , Ming Yuan 3 , Bing Liu 1 , Yiqiong Yang 1 , Wen Cui 1 , Emmanuel Ansong 4 , Huali Dong 4 , Virgilia Macias 4 , Wancai Yang 1, 4 1 Department of Pathology and Institute of Precision Medicine, Jining Medical University, Jining 272067, China 2 Department of Thoracic Surgery, Affiliated Hospital, Jining Medical University, Jining 272067, China 3 Department of Pathology, Xinxiang Medical University, Xinxiang 453003, China 4 Department of Pathology, University of Illinois at Chicago, Chicago, IL 60612, USA * These authors contributed equally to this work Correspondence to: Wancai Yang, email: wyang06@uic.edu Keywords: esophagitis, Barrett's esophagus, squamous cell carcinoma, adenocarcinoma, PLCE1 Received: February 04, 2017 Accepted: March 11, 2017 Published: March 28, 2017 ABSTRACT Esophagitis and Barrett's esophagus are linked to esophageal squamous cell carcinoma and adenocarcinoma, respectively. However, the underlying mechanisms are still unclear. This study analyzed the expression levels of and correlation between PLCE1 and PRKCA in human esophagitis, carcinogen NMBA-induced rat esophagus, PLCE1 genetic deficient mouse esophageal epithelial tissues and human esophageal cancer cell line, integrated with Online oncology data sets. We found that the expression levels of both PLCE1 and PRKCA were significantly elevated in human esophagitis, esophageal squamous cell carcinoma, Barrett's esophagus, esophageal adenocarcinoma and in NMBA-treated rat esophageal epithelia. However, PRKCA and cytokines were significantly downregulated in PLCE1-deficient mouse esophageal epithelia, and knockdown of PLCE1 in human esophageal cancer cells led to reduction of PRKCA and cytokines. Finally, high expression of both PLCE1 and PRKCA is significantly associated with poor outcomes of the patients with esophageal cancers. In conclusion, this study defined the initiation and progression of esophageal inflammation and malignant transformation, in which the positive correlation of PLCE1 and PRKCA exhibits critical clinical significance.