Produção Nacional
Revisado por pares
Environmental risk factors in endemic pemphigus foliaceus (Fogo selvagem)
1992; Elsevier BV; Volume: 98; Issue: 6 Linguagem: Inglês
10.5555/uri
ISSN1523-1747
AutoresClovis Lombardi, Paulo César Borges, Aiçar Chaul, S. A. P. Sampaio, Evandro A. Rivitti, Horácio Friedman, Ciro R. Martins, José Antônio Sanches, Paulo Rowilson Cunha, Raymond G. Hoffmann, Luis A. Díaz,
Tópico(s)Coagulation, Bradykinin, Polyphosphates, and Angioedema
ResumoAbstract Endemic pemphigus foliaceus or Fogo selvagem (FS) is an epidermal organ-specific autoimmune disease mediated by autoantibodies. Individuals at risk are peasants who live and work on farms located in the interior of certain endemic states of Brazil. This case-control study compares a group of 52 FS patients with 52 patients suffering from other dermatoses admitted and followed at the hospital for pemphigus (Hospital do Penfigo) in the city of Goiania, state of Goias. Patients and controls matched 1:1 by age, sex, and occupation were examined by two dermatologists at the time of admission and asked to respond to a prepared questionnaire. This questionnaire concerned current and past (1 and 5 years) exposure to environmental risk factors. The following risk factors were assessed: black fly bites, presence of rodents at home, exposure to cereal dust, exposure to fumes or dust released by tree and shrub removal, and exposure to insecticides. Relative risks were estimated from tabulated data by the odds ratio and tested for significance by the chi-square test. The 95% confidence interval for the odds ratio was also calculated for each of the risk factors. The only risk factor showing an odds ratio significantly different from one was exposure to simuliidae bites (odds ratio 4.7, p
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