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Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children

2017; Elsevier BV; Volume: 187; Linguagem: Inglês

10.1016/j.jpeds.2017.03.007

1097-6833

Kimberly P. Newton, Haruna S. Feldman, Christina Chambers, Laura Wilson, Cynthia Behling, Jeanne M. Clark, Jean P. Molleston, Naga Chalasani, Arun J. Sanyal, Mark Fishbein, Joel E. Lavine, Jeffrey B. Schwimmer, Stephanie H. Abrams, Sarah E. Barlow, Ryan Himes, Rajesh Krisnamurthy, Leanel Maldonado, Rory Mahabir, April Carr, Kimberlee Bernstein, Kristin Bramlage, Kim M. Cecil, Stephanie DeVore, Rohit Kohli, Kathleen D. Lake, Daniel J. Podberesky, Alexander J. Towbin, Stavra A. Xanthakos, Daniela Allende, Srinivasan Dasarathy, Arthur J. McCullough, Mangesh Pagadala, Rish K. Pai, Cha'Ron Winston, Gerald Behr, Joel E. Lavine, Jay H. Lefkowitch, Ali Mencin, Elena Reynoso, Manal F. Abdelmalek, Mustafa R. Bashir, Stephanie Buie, Anna Mae Diehl, Cynthia D. Guy, Christopher Kigongo, David Malik, Yi‐Ping Pan, Dawn Piercy, Mariko Kopping, Tyler Thrasher, Adina Alazraki, Rebecca Cleeton, María Cordero, Albert Altés, Saul J. Karpen, Jessica Cruz Muños, Nicholas Raviele, Miriam B. Vos, Molly Bozic, Naga Chalasani, Oscar W. Cummings, Samer Gawrieh, Ann Klipsch, Jean P. Molleston, Emily Ragozzino, Linda Ragozzino, Kumar Sandrasegaran, Girish Subbarao, Raj Vuppalanchi, Laura Walker, Kimberly Kafka, Ann O. Scheimann, Joy Ito, Mark Fishbein, Saeed Mohammad, Cynthia K. Rigsby, Lisa Sharda, Peter F. Whitington, Sarah E. Barlow, Theresa Cattoor, Jose Derdoy, Janet Freebersyser, Ajay K. Jain, Debra King, Jinping Lai, Pat Osmack, Joan Siegner, Susan D. Stewart, Brent A. Neuschwander‐Tetri, Susan Torretta, Kristina Wriston, F. Assadian, Vanessa Barone, Maria Cardona Gonzalez, Jodie Davila, Oren K. Fix, Kelly Anne Hennessey, Kris V. Kowdley, Katherine I. López, Erik Ness, Michelle Poitevin, Nicholas J. Procaccini, Brook Quist, Alana Saddic, Cara Wiseman, Matthew M. Yeh, Susan S. Baker, Diana Lopez–Graham, Sonja D. Williams, Lixin Zhu, Jonathan A. Africa, Brandon Ang, Hannah I. Awai, Cynthia Behling, Archana Bhatt, Craig Bross, Jennifer Collins, Janis Durelle, Kathryn E. Harlow, Rohit Loomba, Michael S. Middleton, Kimberly P. Newton, Melissa Paiz, Jeffrey B. Schwimmer, Claude B. Sirlin, Patricia Ugalde‐Nicalo, Mariana Dominguez Villarreal, Bradley E. Aouizerat, Nathan M. Bass, Danielle Brandman, Jesse Courtier, Linda D. Ferrell, Natasha A. Feier, Ryan M. Gill, Bilal Hameed, Camille Langlois, Jacqueline Maher, Emily R. Perito, Cláudia Ramos, Philip Rosenthal, Norah A. Terrault, Patrika Tsai, Ashley Ungermann, Pradeep R. Atla, Brandon Croft, Rebekah Garcia, Sonia García, Muhammad Y. Sheikh, Mandeep Singh, Kara Cooper, Simon Horslen, Evelyn Hsu, Karen F. Murray, Randolph K. Otto, Matthew M. Yeh, Melissa Young, Sherry Boyett, Laura R. Carucci, Melissa J. Contos, S. Kirwin, Kenneth A. Kraft, Velimir A. Luketic, Puneet Puri, Arun J. Sanyal, Jolene Schlosser, Mohammad Shadab Siddiqui, Elizabeth M. Brunt, Kathryn J. Fowler, David E. Kleiner, Sherry Brown, Edward Doo, Jay H. Hoofnagle, Patricia R. Robuck, Averell H. Sherker, Rebecca Torrance, Patricia Belt, Jeanne M. Clark, Michele Donithan, Erin Hallinan, Milana Isaacson, Kevin P. May, Laura Miriel, Jürgen Floege, James Tonascia, Mark L. Van Natta, Laura Wilson, Katherine P. Yates,

Pediatric Hepatobiliary Diseases and Treatments

Objectives To examine the distribution of birth weight in children with nonalcoholic fatty liver disease (NAFLD) compared with the general US population, and to investigate the relationship between birth weight and severity of NAFLD. Study design A multicenter, cross-sectional study of children with biopsy-proven NAFLD enrolled in the Nonalcoholic Steatohepatitis Clinical Research Network Database. Birth weight was categorized as low birth weight (LBW), normal birth weight (NBW), or high birth weight (HBW) and compared with the birth weight distribution in the general US population. The severity of liver histology was assessed by birth weight category. Results Children with NAFLD (n = 538) had overrepresentation of both LBW and HBW compared with the general US population (LBW, 9.3%; NBW, 75.8%; HBW, 14.9% vs LBW, 6.1%; NBW, 83.5%; HBW 10.5%; P < .0001). Children with HBW had significantly greater odds of having more severe steatosis (OR, 1.82, 95% CI. 1.15-2.88) and nonalcoholic steatohepatitis (OR, 2.03; 95% CI, 1.21-3.40) compared with children with NBW. In addition, children with NAFLD and LBW had significantly greater odds of having advanced fibrosis (OR, 2.23; 95% CI, 1.08-4.62). Conclusion Birth weight involves maternal and in utero factors that may have long-lasting consequences. Children with both LBW and HBW may be at increased risk for developing NAFLD. Among children with NAFLD, those with LBW or HBW appear to be at increased risk for more severe disease. To examine the distribution of birth weight in children with nonalcoholic fatty liver disease (NAFLD) compared with the general US population, and to investigate the relationship between birth weight and severity of NAFLD. A multicenter, cross-sectional study of children with biopsy-proven NAFLD enrolled in the Nonalcoholic Steatohepatitis Clinical Research Network Database. Birth weight was categorized as low birth weight (LBW), normal birth weight (NBW), or high birth weight (HBW) and compared with the birth weight distribution in the general US population. The severity of liver histology was assessed by birth weight category. Children with NAFLD (n = 538) had overrepresentation of both LBW and HBW compared with the general US population (LBW, 9.3%; NBW, 75.8%; HBW, 14.9% vs LBW, 6.1%; NBW, 83.5%; HBW 10.5%; P < .0001). Children with HBW had significantly greater odds of having more severe steatosis (OR, 1.82, 95% CI. 1.15-2.88) and nonalcoholic steatohepatitis (OR, 2.03; 95% CI, 1.21-3.40) compared with children with NBW. In addition, children with NAFLD and LBW had significantly greater odds of having advanced fibrosis (OR, 2.23; 95% CI, 1.08-4.62). Birth weight involves maternal and in utero factors that may have long-lasting consequences. Children with both LBW and HBW may be at increased risk for developing NAFLD. Among children with NAFLD, those with LBW or HBW appear to be at increased risk for more severe disease.