Harnessing Alkyl Amines as Electrophiles for Nickel-Catalyzed Cross Couplings via C–N Bond Activation
2017; American Chemical Society; Volume: 139; Issue: 15 Linguagem: Inglês
10.1021/jacs.7b02389
ISSN1943-2984
AutoresCorey H. Basch, Jennie Liao, Jianyu Xu, Jacob J. Piane, Mary P. Watson,
Tópico(s)Catalytic C–H Functionalization Methods
ResumoWe developed a strategy to harness alkyl amines as alkylating agents via C-N bond activation. This Suzuki-Miyaura cross coupling of alkylpyridinium salts, readily formed from primary amines, is the first example of a metal-catalyzed cross coupling via C-N bond activation of an amine with an unactivated alkyl group. This reaction enjoys broad scope and functional group tolerance. Primary and secondary alkyl groups can be installed. Preliminary studies suggest a Ni
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