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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Clinical characteristics of patients with cerebellar ataxia associated with anti-GAD antibodies

2017; Thieme Medical Publishers (Germany); Volume: 75; Issue: 3 Linguagem: Inglês

10.1590/0004-282x20170011

ISSN

1678-4227

Autores

Tiago Aguiar, Andrea Fragoso, Carolina Rouanet de Albuquerque, Patrícia de Fátima dos Santos Teixeira, Marcus Vinícius Leitão de Souza, Lenita Zajdenverg, Soniza Vieira Alves‐Leon, Melanie Rodacki, Marco Antônio Lima,

Tópico(s)

Peripheral Neuropathies and Disorders

Resumo

This retrospective and descriptive study evaluated the clinical characteristics and outcomes of patients with CA-GAD-ab.Three patients with cerebellar ataxia, high GAD-ab titers and autoimmune endocrine disease were identified. Patients 1 and 2 had classic stiff person syndrome and insidious-onset cerebellar ataxia, while Patient 3 had pure cerebellar ataxia with subacute onset. Patients received intravenous immunoglobulin therapy with no response in Patients 1 and 3 and partial recovery in Patient 2.CA-GAD-ab is rare and its clinical presentation may hamper diagnosis. Clinicians should be able to recognize this potentially treatable autoimmune cerebellar ataxia.

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