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Artigo Acesso aberto Revisado por pares
BIBTEX RIS

PD-1 blockade with nivolumab in relapsed/refractory primary central nervous system and testicular lymphoma

2017; Elsevier BV; Volume: 129; Issue: 23 Linguagem: Inglês

10.1182/blood-2017-01-764209

ISSN

1528-0020

Autores

Lakshmi Nayak, Fábio M. Iwamoto, Ann S. LaCasce, Srinivasan Mukundan, Margaretha G.M. Roemer, Bjoern Chapuy, Philippe Armand, Scott J. Rodig, Margaret A. Shipp,

Tópico(s)

Vascular Tumors and Angiosarcomas

Resumo

Key Points Genetic analysis reveals frequent 9p24.1/PD-L1/PD-L2 copy-number alterations and increased expression of the PD-1 ligands in PCNSL and PTL. PD-1 blockade with nivolumab demonstrated activity in patients with relapsed/refractory PCNSL and PTL.

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