Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Plasma Brain-Derived Neurotrophic Factor in Women With Pelvic Pain: A Potential Biomarker for Endometriosis?

2017; Future Medicine; Volume: 11; Issue: 4 Linguagem: Inglês

10.2217/bmm-2016-0327

1752-0371

Ana Luiza Lunardi Rocha, Érica Leandro Marciano Vieira, Márcia Cristina França Ferreira, Laura M. Maia, Antônio Lúcio Teixeira, Fernando M. Reis,

Cardiovascular, Neuropeptides, and Oxidative Stress Research

Aim: To test whether plasma BDNF levels are useful to predict the presence of endometriosis in women with pelvic pain. Patients & methods: Prospective cross-sectional study including 67 consecutive women aged 24–49 years, scheduled for laparoscopy due to chronic pelvic pain. Preoperative plasma samples were assayed for BDNF using a commercial enzyme immunoassay. Results: Women with ovarian endometrioma had higher preoperative plasma BDNF (1063 ± 157 pg/ml) compared with women with other benign ovarian tumors (537 ± 131 pg/ml, F = 2.53; p = 0.02). However, plasma BDNF levels were not helpful to indicate the presence of peritoneal or deep infiltrating endometriosis. Plasma BDNF levels were positively correlated with the severity of pelvic pain (r = 0.489; p < 0.0001). Conclusion: Plasma BDNF might be a biomarker of ovarian endometrioma but not a useful diagnostic marker to detect other forms of endometriosis in women with painful symptoms.