Epigenetics and Allergy: from Basic Mechanisms to Clinical Applications
2017; Future Medicine; Volume: 9; Issue: 4 Linguagem: Inglês
10.2217/epi-2016-0162
ISSN1750-1911
AutoresDaniel P. Potaczek, Hani Harb, Sven Michel, Bilal Alashkar Alhamwe, Harald Renz, Jörg Tost,
Tópico(s)Immune Cell Function and Interaction
ResumoAllergic diseases are on the rise in the Western world and well-known allergy-protecting and -driving factors such as microbial and dietary exposure, pollution and smoking mediate their influence through alterations of the epigenetic landscape. Here, we review key facts on the involvement of epigenetic modifications in allergic diseases and summarize and critically evaluate the lessons learned from epigenome-wide association studies. We show the potential of epigenetic changes for various clinical applications: as diagnostic tools, to assess tolerance following immunotherapy or possibly predict the success of therapy at an early time point. Furthermore, new technological advances such as epigenome editing and DNAzymes will allow targeted alterations of the epigenome in the future and provide novel therapeutic tools.
Referência(s)