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Contrast agents in dynamic contrast-enhanced magnetic resonance imaging

2017; Impact Journals LLC; Volume: 8; Issue: 26 Linguagem: Inglês

10.18632/oncotarget.16482

1949-2553

Yuling Yan, Xilin Sun, Baozhong Shen,

Advanced MRI Techniques and Applications

// Yuling Yan 1,2 , Xilin Sun 1,2,3 and Baozhong Shen 1,2 1 Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin, Heilongjiang, China 2 TOF-PET/CT/MR Center, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China 3 Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University School of Medicine, Stanford, California, USA Correspondence to: Baozhong Shen, email: // Xilin Sun, email: // Keywords : DCE-MRI, contrast agent, macromolecular contrast agent, nanoparticle, low molecular contrast agent Received : January 07, 2017 Accepted : March 15, 2017 Published : March 22, 2017 Abstract Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a noninvasive method to assess angiogenesis, which is widely used in clinical applications including diagnosis, monitoring therapy response and prognosis estimation in cancer patients. Contrast agents play a crucial role in DCE-MRI and should be carefully selected in order to improve accuracy in DCE-MRI examination. Over the past decades, there was much progress in the development of optimal contrast agents in DCE-MRI. In this review, we describe the recent research advances in this field and discuss properties of contrast agents, as well as their advantages and disadvantages. Finally, we discuss the research perspectives for improving this promising imaging method.