Clinical and Histological Kidney Involvement in Human Kala-Azar *
1978; American Society of Tropical Medicine and Hygiene; Volume: 27; Issue: 2 Linguagem: Inglês
10.4269/ajtmh.1978.27.357
ISSN1476-1645
AutoresJosé R. Weisinger, Atahualpa Pinto, Gastón A. Velazquez, Isidoro Bronstein, Jean J. Dessene, Juan F. Duque, Juan Manuel Fernández Montenegro, F J Tapanes, Ana Recagno de Rousse,
Tópico(s)Bird parasitology and diseases
ResumoA 19-yr-old woman developed prolonged fever, weight loss, hepatosplenomegaly, anemia, leukopenia, and hyperglobulinemia. Appropriate tests indicated that she had visceral leishmaniasis (kala-azar). Urinalysis demonstrated significant proteinuria and microhematuria with the presence of red cell casts. A kidney biopsy was performed. Light microscopy showed a slight mesangial thickening and segmental mesangial proliferation. Immunofluorescence demonstrated deposits of immunoglobulins A and M, complement, and fibrinogen. Electron microscopy showed subendothelial and intramembranous deposits. After treatment with N-methylglucamine antimonate the proteinuria and microhematuria disappeared and the patient recovered uneventfully.
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