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Recruitment and retention of participants in randomised controlled trials: a review of trials funded and published by the United Kingdom Health Technology Assessment Programme

2017; BMJ; Volume: 7; Issue: 3 Linguagem: Inglês

10.1136/bmjopen-2016-015276

2044-6055

Stephen J. Walters, Inês B. Henriques, Oscar Bortolami, Laura Flight, Daniel Hind, Richard Jacques, Christopher Knox, Ben Nadin, Joanne Rothwell, Michael Surtees, Steven A. Julious,

Health and Medical Research Impacts

Substantial amounts of public funds are invested in health research worldwide. Publicly funded randomised controlled trials (RCTs) often recruit participants at a slower than anticipated rate. Many trials fail to reach their planned sample size within the envisaged trial timescale and trial funding envelope.