Portal de Periódicos da CAPES

Chagas disease immunogenetics: elusive markers of disease progression

2017; Taylor & Francis; Volume: 15; Issue: 5 Linguagem: Inglês

10.1080/14779072.2017.1317591

1744-8344

Yelenca Ortega Zamora, Leidy Johana Escamilla Rojas, Elvis Mayron Villa Sandoval, Joan Steven Vela Porras, Edgar Yarleison Cossio Contrera, Sergio Sebastian Cubides Romero, Pedro David Carreño Ramirez, Hermes Urriago Losada, Carolina De los Rios, Daniela Alejandra Gomez Mahecha, Karen Daniela Lovera Serrano, Juan Carlos Barreto Montaña, Viviana Lorena Narvaez Caicedo, Fredy R. S. Gutierrez,

Parasites and Host Interactions

Introduction: Chagas disease (CD) is caused by a parasitic infection. The disease usually occurs after decades of the primary infection and can involve the myocardium or the digestive system. Of note, around 30% of T. cruzi infected patients develop CD while the other 70% may remain asymptomatic for their entire life. CD is usually observed as familial clustered phenomena. Moreover, individuals with chronic Chagas heart disease (CCHD) usually present a strong, deregulated immune response, which strongly suggests an immunogenetic effect.Areas covered: In this article we review and discuss the information currently available from the published scientific literature regarding the genetic variants of molecules of the immune system that contribute to the clinical presentation of the disease.Expert commentary: Of note, the most promissory results are found on the polymorphisms of chemokine receptors, particularly CCR5 and CCR2. Additional investigations are required, particularly with a focus on the genes that regulate the immune system.