MP16-17 OUTCOMES IN OVER 4,000 PATIENTS WITH RENAL CELL CARCINOMA FROM THE LATIN AMERICAN RENAL CANCER GROUP (LARCG): A FOCUS ON METASTATIC DISEASE
2017; Lippincott Williams & Wilkins; Volume: 197; Issue: 4S Linguagem: Inglês
10.1016/j.juro.2017.02.523
ISSN1527-3792
AutoresDiego Abreu, Guillermo Gueglio, P Sánchez García, Walter da Costa, Daniel Beltrame, Álvaro Zúñiga, Luís Meza, Rubén H. Bengió, Carlos H. Scorticati, Ricardo Castillejos, Francisco Rodríguez, Ana María Autran, Carmen Gonzalez, Miguel Castillo Sánchez, Jose Gadu, Alejandro Nolazco, P.A Marinez, Carlos Ameri, Hamilton de Campos Zampolli, Raúl Langenhin, Diego Muguruza, Marcos Tobías Machado, Antonio Lima Pompeo, Pablo Mingote, Nicolas Ginéstar, Matías López, Boris Camacho, Juan Yandian, Jorge Clavijo, Roberto Puente, Sergio de Miceu, Lucas Nogueira, C Corradi, Marcelo Torrico, Martín Varela, Omar Clark, Luis Montes de, Sebastián Savignano, Ricardo Decia, Fernando P. Secín, Agustín Roberto Rovegno, Gustavo Cardoso Guimarães, Sidney Glina, Carlos E. Palau, Gustavo Franco Carvalhal, Philippe E. Spiess, Stênio de Cássio Zéqui, Marston Linehan,
Tópico(s)Multiple and Secondary Primary Cancers
ResumoYou have accessJournal of UrologyKidney Cancer: Advanced (including Drug Therapy) II1 Apr 2017MP16-17 OUTCOMES IN OVER 4,000 PATIENTS WITH RENAL CELL CARCINOMA FROM THE LATIN AMERICAN RENAL CANCER GROUP (LARCG): A FOCUS ON METASTATIC DISEASE Diego Abreu, Guillermo Gueglio, Patricio Garcia, Walter da Costa, Daniel Beltrame, Alvaro Zuñiga, Luis Meza, Ruben Bengió, Carlos Scorticati, Ricardo Castillejos, Francisco Rodriguez, Ana Maria Autran, Carmen Gonzalez, Miguel Sanchez, Jose Gadu, Alejandro Nolazco, Pablo Marinez, Carlos Ameri, Hamilton Zampolli, Raul Langenhin, Diego Muguruza, Marcos Tobias Machado, Antonio Lima Pompeo, Pablo Mingote, Nicolas Ginéstar, Matías López, Boris Camacho, Juan Yandian, Jorge Clavijo, Roberto Puente, Sergio de Miceu, Lucas Nogueira, Carlos Corradi, Marcelo Torrico, Martin Varela, Omar Clark, Luis Montes de Oca, Sebastian Savignano, Ricardo Decia, Fernando Secin, Agustin Rovegno, Gustavo Guimarães, Sidney Glina, Joan Palau, Gustavo Carvalhal, Philippe Spiess, Stenio Zequi, and Marston Linehan Diego AbreuDiego Abreu More articles by this author , Guillermo GueglioGuillermo Gueglio More articles by this author , Patricio GarciaPatricio Garcia More articles by this author , Walter da CostaWalter da Costa More articles by this author , Daniel BeltrameDaniel Beltrame More articles by this author , Alvaro ZuñigaAlvaro Zuñiga More articles by this author , Luis MezaLuis Meza More articles by this author , Ruben BengióRuben Bengió More articles by this author , Carlos ScorticatiCarlos Scorticati More articles by this author , Ricardo CastillejosRicardo Castillejos More articles by this author , Francisco RodriguezFrancisco Rodriguez More articles by this author , Ana Maria AutranAna Maria Autran More articles by this author , Carmen GonzalezCarmen Gonzalez More articles by this author , Miguel SanchezMiguel Sanchez More articles by this author , Jose GaduJose Gadu More articles by this author , Alejandro NolazcoAlejandro Nolazco More articles by this author , Pablo MarinezPablo Marinez More articles by this author , Carlos AmeriCarlos Ameri More articles by this author , Hamilton ZampolliHamilton Zampolli More articles by this author , Raul LangenhinRaul Langenhin More articles by this author , Diego MuguruzaDiego Muguruza More articles by this author , Marcos Tobias MachadoMarcos Tobias Machado More articles by this author , Antonio Lima PompeoAntonio Lima Pompeo More articles by this author , Pablo MingotePablo Mingote More articles by this author , Nicolas GinéstarNicolas Ginéstar More articles by this author , Matías LópezMatías López More articles by this author , Boris CamachoBoris Camacho More articles by this author , Juan YandianJuan Yandian More articles by this author , Jorge ClavijoJorge Clavijo More articles by this author , Roberto PuenteRoberto Puente More articles by this author , Sergio de MiceuSergio de Miceu More articles by this author , Lucas NogueiraLucas Nogueira More articles by this author , Carlos CorradiCarlos Corradi More articles by this author , Marcelo TorricoMarcelo Torrico More articles by this author , Martin VarelaMartin Varela More articles by this author , Omar ClarkOmar Clark More articles by this author , Luis Montes de OcaLuis Montes de Oca More articles by this author , Sebastian SavignanoSebastian Savignano More articles by this author , Ricardo DeciaRicardo Decia More articles by this author , Fernando SecinFernando Secin More articles by this author , Agustin RovegnoAgustin Rovegno More articles by this author , Gustavo GuimarãesGustavo Guimarães More articles by this author , Sidney GlinaSidney Glina More articles by this author , Joan PalauJoan Palau More articles by this author , Gustavo CarvalhalGustavo Carvalhal More articles by this author , Philippe SpiessPhilippe Spiess More articles by this author , Stenio ZequiStenio Zequi More articles by this author , and Marston LinehanMarston Linehan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.523AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Over the past several years, a major international study collaboration has occurred among centers of excellence caring for kidney cancer termed the Latin American Renal Cancer Group (LARCG). The aim of the present study is to assess the impact of clinical and pathologic variables on cancer specific survival (CSS) and overall survival (OS). METHODS Analysis of data from 28 centers from 8 countries, revealed 4,060 patients with renal cell carcinoma (RCC) who underwent nephrectomy from 1990 to 2015, 530 of which (14.5%) had metastasis at clinical presentation. These are the focus of the present study. Median follow-up was six months (0-162). Of 455 patients with survival data, 203 died (44.6%), 184 (90.6%) of RCC. RESULTS The median age of patients with metastatic RCC (mRCC) was 61 (23-71) years, 68% of patients were male and 32% female (2:1 ratio). The organs most frequently affected with metastasis were lungs (45.5%), bone (21.5%), lymph nodes (10.6%), liver (8.7%), adrenal (4%) and brain (2.2%). On univariate analysis, there were associations between 5-year OS and CSS and presence of ECOG-PS ≥1 (p=0.005 and p=0.007, respectively), ASA 3 classification (p<0.0001, for both), pT 3-4 (p=0.019 and p=0.009 respectively), pN1 (p=0.001 and p<0.0001), Fuhrman grades ≥3 (p=0.010 and p=0.008 respectively), Necrosis (p=0.024 and p=0.016), perirenal fat invasion (p<0.0001, for both), Hemoglobin <11 (p=0.001 and p=0.002), multiple metastases (p=0.002 and p=0.001), two or more involved organs (p=0.002 and p=0.005, respectively), bone vs pulmonary metastasis (p=0.017 and p=0.024), vertebral metastasis (p=0.035, for both), and more than five lungs metastases (p=0.003 for both). On multivariate analysis, the independent prognostic factor of 5-year OS was the ASA (p=0.020). Both OS and CSS were influenced by perirenal fat invasion (p=0.001 for both), and two or more metastatic organ sites (p<0.0001 and p=0.003 respectively). CONCLUSIONS This study of the impact of clinical and pathologic variables on survival in mRCC in Latin America was possible thanks to the collaborative work done by the LARCG. The presence of two or more sites of metastasis and the presence of perirenal fat invasion within the primary tumor predict shorter OS and CSS. ASA Classification was an independent predictor of OS. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e186 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Diego Abreu More articles by this author Guillermo Gueglio More articles by this author Patricio Garcia More articles by this author Walter da Costa More articles by this author Daniel Beltrame More articles by this author Alvaro Zuñiga More articles by this author Luis Meza More articles by this author Ruben Bengió More articles by this author Carlos Scorticati More articles by this author Ricardo Castillejos More articles by this author Francisco Rodriguez More articles by this author Ana Maria Autran More articles by this author Carmen Gonzalez More articles by this author Miguel Sanchez More articles by this author Jose Gadu More articles by this author Alejandro Nolazco More articles by this author Pablo Marinez More articles by this author Carlos Ameri More articles by this author Hamilton Zampolli More articles by this author Raul Langenhin More articles by this author Diego Muguruza More articles by this author Marcos Tobias Machado More articles by this author Antonio Lima Pompeo More articles by this author Pablo Mingote More articles by this author Nicolas Ginéstar More articles by this author Matías López More articles by this author Boris Camacho More articles by this author Juan Yandian More articles by this author Jorge Clavijo More articles by this author Roberto Puente More articles by this author Sergio de Miceu More articles by this author Lucas Nogueira More articles by this author Carlos Corradi More articles by this author Marcelo Torrico More articles by this author Martin Varela More articles by this author Omar Clark More articles by this author Luis Montes de Oca More articles by this author Sebastian Savignano More articles by this author Ricardo Decia More articles by this author Fernando Secin More articles by this author Agustin Rovegno More articles by this author Gustavo Guimarães More articles by this author Sidney Glina More articles by this author Joan Palau More articles by this author Gustavo Carvalhal More articles by this author Philippe Spiess More articles by this author Stenio Zequi More articles by this author Marston Linehan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
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