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Ivermection-loaded solid lipid nanoparticles: preparation, characterisation, stability and transdermal behaviour

2017; Informa; Volume: 46; Issue: 2 Linguagem: Inglês

10.1080/21691401.2017.1307207

2169-141X

Dawei Guo, Dandan Dou, Xinyu Li, Qian Zhang, Zohaib Ahmed Bhutto, Liping Wang,

Bee Products Chemical Analysis

To avoid potential systematical toxicity, solid lipid nanoparticles (SLNs) were prepared as a vehicle for transdermal delivery of ivermectin (IVM) using hot homogenisation followed by ultrasonic method. The as-prepared SLNs were approximately spherical shape with good stability. IVM was encapsulated in amorphous form within SLNs and displayed prolonged release from SLNs without burst release due to high encapsulation efficiency (EE). The cumulative permeation of IVM across excised rat skin from SLNs was significantly increased compared to the ivermection suspension. These results indicated that the proposed SLNs can be considered as an efficient carrier for dermal delivery of IVM to effectively treat scabies.