Eat to Live or Live to Eat? The Neurobiology of Appetite Regulation
2017; Elsevier BV; Volume: 81; Issue: 9 Linguagem: Inglês
10.1016/j.biopsych.2017.02.1177
ISSN1873-2402
AutoresKathryn Kinasz, David A. Ross, Joseph J. Cooper,
Tópico(s)Adipose Tissue and Metabolism
ResumoFrom Dante's Inferno ( 1 Alghieri D. Doré G. Dante's inferno, new ed. [Cary HF, trans.]. Charles C. Thompson Co, Chicago1885http://hdl.handle.net/2027/uiug.30112001610424 Google Scholar ), composed in the 14th century, to Roald Dahl's Charlie and the Chocolate Factory ( 2 Dahl R. Charlie and the Chocolate Factory. Puffin Books, New York2004 Google Scholar ), centuries of literature consistently portray obese characters as vile and unrestrained. Even today, the continued stigma associated with obesity may contribute to many biopsychosocial problems, including mental health disorders, substance use, and stress ( 3 Papadopoulos S. Brennan L. Correlates of weight stigma in adults with overweight and obesity: A systematic literature review. Obesity. 2015; 23: 1743-1760 Crossref PubMed Scopus (159) Google Scholar ). As worldwide obesity rates rise ( 4 Val-Laillet D. Aarts E. Weber B. Ferrari M. Quaresima V. Stoeckel L.E. et al. Neuroimaging and neuromodulation approaches to study eating behavior and prevent and treat eating disorders and obesity. Neuroimage Clin. 2015; 8: 1-31 Crossref PubMed Scopus (270) Google Scholar ) we are only now coming to appreciate the neurobiological underpinnings of what has often been construed as willful self-indulgence. Leptin Dysregulation Is Specifically Associated With Major Depression With Atypical Features: Evidence for a Mechanism Connecting Obesity and DepressionBiological PsychiatryVol. 81Issue 9PreviewObesity-related dysregulation of leptin signaling (e.g., hyperleptinemia due to central functional resistance) may affect mood. However, evidence for leptin dysregulation in major depressive disorder (MDD) is conflicting. Inconclusive findings may be attributable to heterogeneity of MDD, aggregating biologically different subtypes. We examined the relationship of leptin with MDD, its common subtypes (typical and atypical), and clinical features. Full-Text PDF
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