Portal de Periódicos da CAPES

SynergyFinder: a web application for analyzing drug combination dose–response matrix data

2017; Oxford University Press; Volume: 33; Issue: 15 Linguagem: Inglês

10.1093/bioinformatics/btx162

1367-4811

Aleksandr Ianevski, Liye He, Tero Aittokallio, Jing Tang,

Statistical Methods in Clinical Trials

Rational design of drug combinations has become a promising strategy to tackle the drug sensitivity and resistance problem in cancer treatment. To systematically evaluate the pre-clinical significance of pairwise drug combinations, functional screening assays that probe combination effects in a dose-response matrix assay are commonly used. To facilitate the analysis of such drug combination experiments, we implemented a web application that uses key functions of R-package SynergyFinder, and provides not only the flexibility of using multiple synergy scoring models, but also a user-friendly interface for visualizing the drug combination landscapes in an interactive manner.The SynergyFinder web application is freely accessible at https://synergyfinder.fimm.fi ; The R-package and its source-code are freely available at http://bioconductor.org/packages/release/bioc/html/synergyfinder.html .jing.tang@helsinki.fi.