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Tau protein, the paired helical filament and Alzheimer's disease

2006; IOS Press; Volume: 9; Issue: s3 Linguagem: Inglês

10.3233/jad-2006-9s323

1875-8908

Michel Goedert, Aaron Klug, R. Anthony Crowther,

Mitochondrial Function and Pathology

In 1906, Alzheimer described the clinical and neuropathological characteristics of the disease that was subsequently named after him. Although the paired helical filament was identified as the major component of the neurofibrillary pathology of Alzhe