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Artigo Produção Nacional Revisado por pares
BIBTEX RIS

Periodontitis changes renal structures by oxidative stress and lipid peroxidation

2017; Wiley; Volume: 44; Issue: 6 Linguagem: Inglês

10.1111/jcpe.12729

ISSN

1600-051X

Autores

Luíz Felipe de Carvalho França, Any Carolina Cardoso Guimarães Vasconcelos, Felipe Rodolfo Pereira da Silva, Even Herlany Pereira Alves, Joaquina S. Carvalho, David Di Lenardo, Luan Kelves Miranda de Souza, André Luiz dos Reis Barbosa, Jand Venes Rolim Medeiros, Jefferson Soares de Oliveira, Daniel Fernando Pereira Vasconcelos,

Tópico(s)

Oral Health Pathology and Treatment

Resumo

The aim of this study was to investigate whether experimental periodontitis cause changes to the renal tissues and imbalance in oxidative stress in kidneys.Twenty-two female Wistar rats were separated into two groups: control and periodontitis. We assessed the following parameters: gingival bleeding index (GBI), tooth mobility, gum malondialdehyde (MDA), myeloperoxidase (MPO) activity, probing pocket depth (PPD), alveolar bone loss (ABL) for periodontal tissues; histomorphometric measures associated with renal corpuscle and histopathological aspects (evaluation of brush border) for kidneys; as also blood and urine biomarkers. Finally, we evaluated renal oxidative stress through glutathione (GSH) and MDA respectively.With regard to renal histomorphometry, significant differences were observed in all parameters assessed. In relation periodic acid Schiff (PAS) staining, disruption was observed of brush border in the periodontitis group in the renal tubules in comparison with the control group. The periodontitis group presented significantly higher MDA and lower GSH concentrations in the kidneys compared with animals without periodontitis.The induced periodontitis caused histomorphometric changes in renal tissues as well as disruption of the brush border in renal tubules, alterations associated with increase in oxidative stress in kidneys. However, these alterations were not sufficient to cause differences in the renal function markers.

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